Heart Failure Research Institute

Advancing the understanding, prevention, and treatment of heart failure through research

Our Research

Our world-renowned experts, including physicians and scholars from Weill Cornell Medicine and Columbia University Vagelos College of Physicians and Surgeons, are on the leading edge of heart failure research. 

Discover our latest publications, areas of interest, and how we’re advancing the field.

physician doing research
Heart failure

The Difference Between Cystatin C- and Creatinine-Based Estimated GFR in Heart Failure With Reduced Ejection Fraction: Insights From PARADIGM-HF.

Pinsino A, Carey MR, Husain S, Mohan S, Radhakrishnan J, Jennings DL, Nguonly AS, Ladanyi A, Braghieri L, Takeda K, Faillace RT, Sayer GT, Uriel N, Colombo PC, Yuzefpolskaya M. Am J Kidney Dis. 2023 Nov;82(5):521-533. doi: 10.1053/j.ajkd.2023.03.005. Epub 2023 Apr 20.

 

Malnutrition in heart failure with preserved ejection fraction.

Zainul O, Perry D, Pan M, Lau J, Zarzuela K, Kim R, Konerman MC, Hummel SL, Goyal P. J Am Geriatr Soc. 2023 Nov;71(11):3367-3375. doi: 10.1111/jgs.18590. Epub 2023 Sep 14.

 

Fulminant myocarditis proven by early biopsy and outcomes.

Huang F, Ammirati E, Ponnaiah M, Montero S, Raimbault V, Abrams D, Lebreton G, Pellegrino V, Ihle J, Bottiroli M, Persichini R, Barrionuevo-Sánchez MI, Ariza-Solé A, Ng PY, Sin SWC, Ayer R, Buscher H, Belaid S, Delmas C, Ferreira R, Albuquerque RR Jr, Lόpez-Sobrino T, Bunge JJH, Fisser C, Franchineau G, McCanny J, Ohshimo S, Sionis A, Hernández-Pérez FJ, Barge-Caballero E, Balik M, Muglia H, Park S, Donker DW, Porral B, Aïssaoui N, Mekontso Dessap A, Burgos V, Lesouhaitier M, Fried J, Jung JS, Rosillo S, Scherrer V, Nseir S, Winszewski H, Jorge-Pérez P, Kimmoun A, Diaz R, Combes A, Schmidt M; FULLMOON Study Group. Eur Heart J. 2023 Nov 6:ehad707. doi: 10.1093/eurheartj/ehad707. Online ahead of print.

 

Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension.

Lowery MM, Hill NS, Wang L, Rosenzweig EB, Bhat A, Erzurum S, Finet JE, Jellis CL, Kaur S, Kwon DH, Nawabit R, Radeva M, Beck GJ, Frantz RP, Hassoun PM, Hemnes AR, Horn EM, Leopold JA, Rischard FP, Mehra R; Pulmonary Vascular Disease Phenomics (PVDOMICS) Study Group.J Am Coll Cardiol. 2023 Nov 21;82(21):1989-2005. doi: 10.1016/j.jacc.2023.09.806.

 

Reverse Remodeling Effects of Sacubitril-Valsartan: Structural and Functional Optimization in Stage C Heart Failure.

Kalanatari S, Oren D, Medvedofsky D, Narang A, Imamura T, Tayazime S, Kim GH, Raikhelkar J, Sayer G, Lang RM, Uriel N. Am J Cardiol. 2024 Jan 1;210:249-255. doi: 10.1016/j.amjcard.2023.09.110. Epub 2023 Oct 24.

 

Health Status in Heart Failure and Cancer: Analysis of the Medicare Health Outcomes Survey 2016-2020.

Shah KP, Khan SS, Baldridge AS, Grady KL, Cella D, Goyal P, Allen LA, Smith JD, Lagu TC, Ahmad FS.JACC Heart Fail. 2023 Oct 30:S2213- 1779(23)00678-9. doi: 10.1016/j.jchf.2023.10.003. Online ahead of print.

 

Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension.

Simpson CE, Ambade AS, Harlan R, Roux A, Aja S, Graham D, Shah AA, Hummers LK, Hemnes AR, Leopold JA, Horn EM, Berman-Rosenzweig ES, Grunig G, Aldred MA, Barnard J, Comhair SAA, Tang WHW, Griffiths M, Rischard F, Frantz RP, Erzurum SC, Beck GJ, Hill NS, Mathai SC, Hassoun PM, Damico RL; the PVDOMICS Study Group. Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L617-L627. doi: 10.1152/ajplung.00177.2023. Epub 2023 Oct 3.

 

Heart failure medical therapy prior to mitral transcatheter edge-to-edge repair: the STS/ACC Transcatheter Valve Therapy Registry.

Varshney AS, Shah M, Vemulapalli S, Kosinski A, Bhatt AS, Sandhu AT, Hirji S, DeFilippis EM, Shah PB, Fiuzat M, O'Gara PT, Bhatt DL, Kaneko T, Givertz MM, Vaduganathan M. Eur Heart J. 2023 Nov 21;44(44):4650-4661. doi: 10.1093/eurheartj/ehad584.

 

Social Determinants of Health and Cardiologist Involvement in the Care of Adults Hospitalized for Heart Failure.

Zhang DT, Onyebeke C, Nahid M, Balkan L, Musse M, Pinheiro LC, Sterling MR, Durant RW, Brown TM, Levitan EB, Safford MM, Goyal P. JAMA Netw Open. 2023 Nov 1;6(11):e2344070. doi: 10.1001/jamanetworkopen.2023.44070.

 

Diagnostic Value of High-Sensitivity Cardiac Troponin-I in Patients After Out-of-Hospital Cardiac Arrest.

Elad B, Aronson D, Cohn-Schwartz D, Kapeliovich M.Am J Cardiol. 2023 Nov 15;207:253-256. doi: 10.1016/j.amjcard.2023.08.182. Epub 2023 Sep 26.

 

Risk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification.

Ghosh AK, Venkatraman S, Nanna MG, Safford MM, Colantonio LD, Brown TM, Pinheiro LC, Peterson ED, Navar AM, Sterling MR, Soroka O, Nahid M, Banerjee S, Goyal P. JAMA Cardiol. 2023 Dec 6:e234520. doi: 10.1001/jamacardio.2023.4520. Online ahead of print.

 

Disparities in Guideline Concordant Statin Treatment in Individuals With Chronic Obstructive Pulmonary Disease.

Krishnan JK, Mallya SG, Nahid M, Baugh AD, Han MK, Aronson KI, Goyal P, Pinheiro LC, Banerjee S, Martinez FJ, Safford MM. Chronic Obstr Pulm Dis. 2023 Oct 26;10(4):369-379. doi: 10.15326/jcopdf.2023.0395.

 

Assessing and managing frailty in advanced heart failure: An International Society for Heart and Lung Transplantation consensus statement.

Denfeld QE, Jha SR, Fung E, Jaarsma T, Maurer MS, Reeves GR, Afilalo J, Beerli N, Bellumkonda L, De Geest S, Gorodeski EZ, Joyce E, Kobashigawa J, Mauthner O, McDonagh J, Uchmanowicz I, Dickson VV, Lindenfeld J, Macdonald P. J Heart Lung Transplant. 2023 Nov 29:S1053-2498(23)02028-4. doi: 10.1016/j.healun.2023.09.013. Online ahead of print.

 

Sex Disparities in the Management, Outcomes, and Transfer of Patients Hospitalized for Cardiogenic Shock.

Luna P, Kim LK, Yeo I, Narula N, Steitieh D, Subramanyam P, Karas MG, Iannacone EM, Naka Y, Girardi NI, Srivastava A, Majure DT, Kanduri J, Horn EM, Cheung JW, Feldman DN, Lu DY. J SCAI. 2023 Nov; 101212. Epub 2023 Nov 10.

 

Artificial intelligence/Remote patient monitoring

Using Patient Decision Aids for Cardiology Care in Diverse Populations.

Masterson Creber R, Benda N, Dimagli A, Myers A, Niño de Rivera S, Omollo S, Sharma Y, Goyal P, Turchioe MR. Curr Cardiol Rep. 2023 Nov;25(11):1543-1553. doi: 10.1007/s11886-023-01953-z. Epub 2023 Nov 9.

A Novel Digital Platform for Cardiac Rehabilitation: Implementation and Performance During Extreme Health Crisis.

Elad B, Promyslovsky M, Eisen I, Helmer L, Ben Gal S, Caspi O. J Cardiopulm Rehabil Prev. 2023 Nov 1;43(6):E25-E27. doi: 10.1097/HCR.0000000000000811. Epub 2023 Jul 4.

Amyloidosis

Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis.

Maurer MS, Kale P, Fontana M, Berk JL, Grogan M, Gustafsson F, Hung RR, Gottlieb RL, Damy T, González-Duarte A, Sarswat N, Sekijima Y, Tahara N, Taylor MS, Kubanek M, Donal E, Palecek T, Tsujita K, Tang WHW, Yu WC, Obici L, Simões M, Fernandes F, Poulsen SH, Diemberger I, Perfetto F, Solomon SD, Di Carli M, Badri P, White MT, Chen J, Yureneva E, Sweetser MT, Jay PY, Garg PP, Vest J, Gillmore JD; APOLLO-B Trial Investigators. N Engl J Med. 2023 Oct 26;389(17):1553-1565. doi: 10.1056/NEJMoa2300757.

 

The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology.

Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. J Card Fail. 2023 Oct 30:S1071-9164(23)00379-2. doi: 10.1016/j.cardfail.2023.09.016. Online ahead of print.

 

A 15-year consolidated overview of data in over 6000 patients from the Transthyretin Amyloidosis Outcomes Survey (THAOS).

Gentile L, Coelho T, Dispenzieri A, Conceição I, Waddington-Cruz M, Kristen A, Wixner J, Diemberger I, Gonzalez-Moreno J, Cariou E, Maurer MS, PlantéBordeneuve V, Garcia-Pavia P, Tournev I, Gonzalez-Costello J, Duarte AG, Grogan M, Mazzeo A, Chapman D, Gupta P, Glass O, Amass L; THAOS investigators. Orphanet J Rare Dis. 2023 Nov 10;18(1):350. doi: 10.1186/s13023-023-02962-5.

 

Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy: A Post Hoc Analysis of the ATTR-ACT Randomized Clinical Trial.

Shah SJ, Fine N, Garcia-Pavia P, Klein AL, Fernandes F, Weissman NJ, Maurer MS, Boman K, Gundapaneni B, Sultan MB, Elliott P. JAMA Cardiol. 2023 Nov 15:e234147. doi: 10.1001/jamacardio.2023.4147. Online ahead of print.

 

Effect of Eplontersen on Cardiac Structure and Function in Patients With Hereditary Transthyretin Amyloidosis.

Masri A, Maurer MS, Claggett BL, Kulac I, Waddington Cruz M, Conceição I, Weiler M, Berk JL, Gertz M, Gillmore JD, Rush S, Chen J, Zhou W, Kwoh J, Duran JM, Tsimikas S, Solomon SD. J Card Fail. 2023 Dec 7:S1071-9164(23)00894-1. doi: 10.1016/j.cardfail.2023.11.016. Online ahead of print.

 

Recognizing Cardiac Amyloidosis Phenotype by Echocardiography Increases Downstream Testing.

Miller P, Maurer MS, Einstein AJ, Elias P, Poterucha TJ. J Am Soc Echocardiogr. 2023 Dec;36(12):1326-1329. doi: 10.1016/j.echo.2023.08.018. Epub 2023 Aug 26.

 

Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases.

Chan N, Einstein AJ, Griffin JM, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson LL, Kinkhabwala MP, Leb JS, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith SE, Winburn M, Smiley D, Miller EJ, Ruberg FL, Maurer MS. J Nucl Cardiol. 2023 Dec;30(6):2531-2539. doi: 10.1007/s12350-023-03310-7. Epub 2023 Jun 13.

 

Safety and efficacy of teclistamab in systemic immunoglobulin light chain amyloidosis.

Chakraborty R, Bhutani D, Maurer MS, Mohan M, Lentzsch S, D'Souza A. Blood Cancer J. 2023 Nov 27;13(1):172. doi: 10.1038/s41408-023-00950-3.

 

Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay.

Coelho T, Dispenzieri A, Grogan M, Conceição I, Waddington-Cruz M, Kristen AV, Wixner J, Diemberger I, Gonzalez-Moreno J, Maurer MS, PlantéBordeneuve V, Garcia-Pavia P, Tournev I, Gonzalez-Costello J, Cariou E, González-Duarte A, Glass O, Chapman D, Amass L; THAOS investigators. Amyloid. 2023 Dec;30(4):445-448. doi: 10.1080/13506129.2023.2229484. Epub 2023 Jul 17.

 

Reduced early mortality with Daratumumab-based frontline therapy in AL amyloidosis: A retrospective cohort study.

Chakraborty R, Bhutani D, Mapara M, Reshef R, Maurer MS, Radhakrishnan J, Lentzsch S. Am J Hematol. 2023 Dec 15. doi: 10.1002/ajh.27179. Online ahead of print.

Cardiogenic shock & mechanical circulatory support

Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial.

Mehra MR, Netuka I, Uriel N, Katz JN, Pagani FD, Jorde UP, Gustafsson F, Connors JM, Ivak P, Cowger J, Ransom J, Bansal A, Takeda K, Agarwal R, Byku M, Givertz MM, Bitar A, Hall S, Zimpfer D, Vega JD, Kanwar MK, Saeed O, Goldstein DJ, Cogswell R, Sheikh FH, Danter M, Pya Y, Phancao A, Henderson J, Crandall DL, Sundareswaran K, Soltesz E, Estep JD; ARIES-HM3 Investigators. JAMA. 2023 Dec 12;330(22):2171-2181. doi: 10.1001/jama.2023.23204.

 

Stroke and Mechanical Circulatory Support in Adults.

Bae DJ, Willey JZ, Ibeh C, Yuzefpolskaya M, Colombo PC. Curr Cardiol Rep. 2023 Nov 3. doi: 10.1007/s11886-023-01985-5. Online ahead of print.

 

Is it time to stop living in a HeartMate II world?

Yuzefpolskaya M, Fiedler AG, Katz JN, Houston BA. J Heart Lung Transplant. 2023 Nov;42(11):1621-1626. doi: 10.1016/j.healun.2023.07.014. Epub 2023 Aug 1.

 

How I manage differential gas exchange in peripheral venoarterial extracorporeal membrane oxygenation.

Asija R, Fried JA, Siddall EC, Mullin DA, Agerstrand CL, Brodie D, Sonett JR, Lemaitre PH, Abrams D. Crit Care. 2023 Oct 27;27(1):408. doi: 10.1186/s13054-023-04703-3.

 

Commentary: Early extracorporeal membrane oxygenation strategy for postcardiotomy shock.

Kaku Y, Chung MM, Takayama H. J Thorac Cardiovasc Surg. 2023 Dec;166(6):1683. doi: 10.1016/j.jtcvs.2023.05.008. Epub 2023 Jun 2.

 

Pumping for Two: Pregnancy in Patients Supported With a Left Ventricular Assist Device.

Oren D, Moeller CM, Haythe JH, Rubinstein G, Fernandez Valledor A, Lotan D, Rosenblum H, Colombo PC, Yuzefpolskaya M, Topkara VK, Clerkin KJ, Raikhelkar JK, Fried JA, Naka Y, Takeda K, Latif F, Sayer G, Uriel N. ASAIO J. 2023 Nov 7. doi: 10.1097/MAT.0000000000002082. Online ahead of print.

 

Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation-analysis of the Extracorporeal Life Support Organization registry.

Fernando SM, MacLaren G, Barbaro RP, Mathew R, Munshi L, Madahar P, Fried JA, Ramanathan K, Lorusso R, Brodie D, McIsaac DI. Intensive Care Med. 2023 Dec;49(12):1456-1466. doi: 10.1007/s00134-023-07199-1. Epub 2023 Oct 4.

 

Myocardial Recovery With HeartMate 3 Left Ventricular Assist Device: An Attainable Goal That Needs Better Precision.

Liang LW, Ladanyi A, Kennel PJ, Axsom KM, Sayer GT, Takeda K, Sekulic M, Uriel N, Drakos S, Colombo PC, Yuzefpolskaya M. ASAIO J. 2023 Nov 14. doi: 10.1097/MAT.0000000000002099. Online ahead of print.

 

Acute Right Ventricular Geometric Change Predicts Outcomes in HeartMate 3 Patients.

Hayashi H, Kirschner M, Vinogradsky A, Ning Y, Kurlansky P, Yuzefpolskaya M, Colombo PC, Sayer GT, Uriel N, Naka Y, Takeda K. J Heart Lung Transplant. 2023 Dec 7:S1053-2498(23)02158-7. doi: 10.1016/j.healun.2023.11.020. Online ahead of print.

 

Clinical Outcomes With a Fully Magnetically Levitated Left Ventricular Assist Device Among Women and Men.

Ramu B, Cogswell R, Ravichandran AK, Cleveland J Jr, Mehra MR, Goldstein D, Uriel N, Dirckx N, Ahmed S, Yuzefpolskaya M. JACC Heart Fail. 2023 Dec;11(12):1692-1704. doi: 10.1016/j.jchf.2023.08.020. Epub 2023 Oct 11.

 

Venovenous extracorporeal membrane oxygenation for respiratory failure refractory to high frequency percussive ventilation.

Worku B, Khin S, Wong I, Gambardella I, Mack C, Srivastava A, Tukacs M, Khusid F, Malik S, Balaram S, Reisman N, Gulkarov I. Heart Lung. 2023 Nov 15;64:1-5. doi: 10.1016/j.hrtlng.2023.10.014. Online ahead of print.

 

Concurrent valvular procedures during left ventricular assist device implantation and outcomes: A comprehensive analysis of the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 trial portfolio.

John R, Kanwar MK, Cleveland JC Jr, Uriel N, Naka Y, Salerno C, Horstmanshof D, Hall SA, Cowger JA, Heatley G, Somo SI, Mehra MR. J Thorac Cardiovasc Surg. 2023 Dec;166(6):1684-1694.e18. doi: 10.1016/j.jtcvs.2022.04.021. Epub 2022 Apr 25.

 

Acute kidney injury during extracorporeal life support in cardiogenic shock: Does flow matter?

Vaynrub A, Ning Y, Kurlansky P, Wang AS, Beck J, Fried JA, Takeda K. Perfusion. 2023 Dec 12:2676591231220793. doi: 10.1177/02676591231220793. Online ahead of print.

 

Trends in the Incidence of Cardiogenic Shock, and Utilization of Mechanical Circulatory Support in Myocarditis: Insights from the National Inpatient Sample 2016 to 2019.

Steitieh D, Klahr R, Greenfest A, Xu S, Cheung JW, Feldman DN, Singh HS, Minutello RM, Wong SC, Wang J, Lu DY, Karas MG, Kim LK. Am J Cardiol. 2023 Oct 15;205:406-412.

Cardio-oncology

In Vitro Assessment of Cisplatin/Hyaluronan Complex for Loco-Regional Chemotherapy.

Banella S, Saraswat A, Patel A, Serajuddin ATM, Colombo P, Patel K, Colombo G. Int J Mol Sci. 2023 Oct 29;24(21):15725. doi: 10.3390/ijms242115725.