Advances in Care

The Network Effect: Analyzing Brain Structures to Treat Depression

Episode 14
The Network Effect: Analyzing Brain Structures to Treat Depression
The Network Effect: Analyzing Brain Structures to Treat Depression

When Dr. Conor Liston first began mapping the brains of people suffering from major depression he noticed something strange. In depressed brains certain networks were expanded and, as a result, had pushed into other networks. This finding made Dr. Liston think that the expanded network could explain why depression presents differently from patient to patient. His work mapping the brain could be the key to effectively using Transcranial Magnetic Stimulation (TMS) to help patients with treatment resistant depression.

For any patient diagnosed with depression for the first time, the recommended course of treatment is the same: a medication like a selective serotonin reuptake inhibitor (SSRI), an evidence based psychotherapy, or both. But there is a large group of people for whom these treatments simply won't work. That’s where Dr. Conor Liston and his team focus. His work mapping the brain is helping doctors better understand where depression is impacting certain brain structures and what that means for the symptoms patients present. Dr. Liston’s work is focused on identifying how these symptoms impact patients' brains and using those findings to identify the best treatment approach. It also may eventually help detect the likelihood of depression in patients before they exhibit any symptoms.