Find A Physician

Return to Treatment of Advanced Disease Overview

More on Treatment of Advanced Disease

Hospital News

Return to Treatment of Advanced Disease Overview

More on Treatment of Advanced Disease

Research and Clinical Trials

Return to Treatment of Advanced Disease Overview

More on Treatment of Advanced Disease

Clinical Services

Return to Treatment of Advanced Disease Overview

More on Treatment of Advanced Disease

Weill Cornell Cancer Center

Treatment of Advanced Disease

Men with prostate cancer that has spread beyond the prostate, those who cannot undergo radiation therapy or surgery, and those whose cancer has returned following surgery or radiation therapy may need

Hormonal therapy is often used to slow prostate cancer growth by reducing the amount of testosterone in the body. This approach can be effective for many years. However, many men who receive this treatment will ultimately experience continued growth of their prostate cancer. Weill Cornell researchers are exploring new approaches for treating men with such "hormone-resistant prostate cancer."

For example, Weill Cornell researchers developed J591, an antibody designed to target the blood supply of tumors by binding to a protein called prostate-specific membrane antigen (PSMA). PSMA has been an attractive target for cancer drug development because it is not only present in high amounts in prostate cancers; it is also the only known molecular target present on tumor blood vessels, but not normal blood vessels. The ability to target PSMA on blood vessels would provide a way to directly attack a tumor's blood supply without affecting normal blood vessels, with the goal of blocking a tumor's ability to grow and spread. The J591 antibody is being evaluated at Weill Cornell in clinical trials in patients with advanced prostate cancer.

Weill Cornell investigators are collaborating with scientists at Cornell University's Ithaca campus to devise a microfluidic device to identify prostate cancer cells in the blood. The goal is to use the tool to see how circulating tumor cells correlate with a patient's response to chemotherapy and to identify genetic abnormalities that can be used to develop novel targeted therapies.

Clinical Trials

Weill Cornell also offers a range of other clinical trials evaluating new treatments for advanced prostate cancer.

Find a prostate cancer clinical trial at the Weill Cornell Cancer Center.

Find a prostate cancer clinical trial at the Weill Cornell Department of Urology.

  • Bookmark
  • Print

    Find a Doctor

Click the button above or call
1 877 NYP WELL


eNewsletters
Top of page