The team at the Comprehensive Center for Congenital Adrenal Hyperplasia (CAH) conducts basic science and clinical research. The shared goal of their efforts is to advance the treatment of CAH and improve the lives of people affected by it.
Current research efforts are aimed at:
- Optimizing steroid dosing at all stages of a patient's life(during well periods as well as times of illness, stress, and injury).
- Our physicians conduct a study that examines the appropriate doses of steroid replacement in children with CAH who undergo surgery. The study is actively enrolling patients.
- Metformin therapy in addition glucocorticoid therapy in young girls with CAH. The study wants to determine if Metformin helps these patients achieve better hormonal control. It is waiting IRB approval.
- Studying the long-term outcome of children with CAH who have obesity and insulin resistance. This study is now under development.
- Assessing the psychological effects of CAH and its influence on quality of life and development. The study is actively enrolling patients.
- Our investigators are also examining the roles of androgen receptors (AR) and estradiol receptors (ER) in genital development. They characterized AR and ER in the genital tissue of females with CAH. They found both AR and ER in erectile tissue from these patients, with a tendency toward higher AR expression in Prader 5 patients compared with Prader 4 patients. These results provide insights into the development of both AR and ER in genitourinary tissue. The results of additional studies may lead to pharmacologic intervention as an adjunct to CAH treatment.
If you would like to participate or learn more about our studies, please contact Maria Aranda at 646-962-2316.
Select Publications from our Team
- Lekarev O, Tafuri K, Lane AH, Zhu G, Nakamoto JM, Buller-Burckle AM, Wilson TA, New MI. Erroneous prenatal diagnosis of congenital adrenal hyperplasia owing to a duplication of the CYP21A2 gene. J Perinatol. 2013 Jan;33(1):76-8. doi: 10.1038/jp.2012.5. Link to article online at PubMed
- Choudhary A, Spigland N, Poppas D, Kovanlikaya A, Nimkarn S. Vaginal bleeding leading to incidental diagnosis of ovarian torsion in an infant with 21 hydroxylase deficiency congenital adrenal hyperplasia. J Pediatr. 2013 Feb;162(2):432-432. Link to article online at PubMed
- Lin-Su K, Harbison MD, Lekarev O, Vogiatzi MG, New MI. Final adult height in children with congenital adrenal hyperplasia treated with growth hormone. J Clin Endocrinol Metab. 2011 Jun;96(6):1710-7. doi: 10.1210/jc.2010-2699. Epub 2011 Mar 30. Link to article online at PubMed
- Lekarev O, New MI. Adrenal disease in pregnancy. Best Pract Res Clin Endocrinol Metab. 2011 Dec;25(6):959-73. Link to article online at PubMed
- Cabrera MS, Vogiatzi MG, New MI. Long term outcome in adult males with classic congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2001 Jul;86(7):3070-8. Link to article online at JCEM